Ribosomal proteins: a novel class of oncogenic drivers
نویسندگان
چکیده
منابع مشابه
Ribosomal proteins: a novel class of oncogenic drivers
With a diameter of ~30 nm and a mass of ~4.3 MDa, human ribosomes are structurally and functionally sophisticated cytoplasmic giants. Half of this mass comes from the 81 ribosomal proteins (RPs) which, formerly erroneously believed to simply act as dispensable assistants of the catalytic ribosomal RNA (rRNA), are in many cases essential for ribosomal functioning. Ribosomes can mechanistically b...
متن کاملInteraction of viral oncogenic proteins with the Wnt signaling pathway
It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses, plays an important role in viral carcinogenes...
متن کاملMutant Cbl proteins as oncogenic drivers in myeloproliferative disorders
Casitas B-lineage lymphoma (Cbl) family proteins are evolutionarily-conserved attenuators of protein tyrosine kinase (PTK) signaling. Biochemical analyses over the past two decades have firmly established that the negative regulatory functions of Cbl proteins are mediated through their ability to facilitate ubiquitination and thus promote degradation of PTKs. As aberrant activation of PTKs is f...
متن کاملTargeting oncogenic drivers.
Cancer is a genetic disease caused by a series of somatic and/or germline mutations. The roles of oncogenes and tumor suppressors in cancer molecular origin have been well established. Targeting oncogene products has become an attractive therapeutic strategy with great clinical success, whereas tumor suppressors are considered 'undruggable' because current technology is not able to restore tumo...
متن کاملA Novel Class of RanGTP Binding Proteins
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Although Ran has been implicated also in a variety of other processes, such as cell cycle progression, a direct function of Ran has so far only been demonstrated for importin-mediated nuclear import. We have now identified an entire class of approximately 20 potent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.20802